Your ultimate guide to traveling Italy by train

Ah, Italy. The cuisine, the art, the locals, the landscapes, and of course, the towering scoops of gelato you’ll indulge in nightly. Once you arrive, you'll want to experience everything, and there’s no better way than by train as you traverse the countryside (unless, perhaps, you have a private luxury limo with a backseat bar—but if that were the case, you probably wouldn’t need this guide). We've crafted a train itinerary that showcases the highlights, like a curated tour just for you. Enjoy!

Day One

Venice

Begin your adventure in Venice with an early morning walk across the iconic Rialto Bridge, then make your way to Piazza San Marco for your first cup of coffee. This piazza is the vibrant center of Venice, featuring St. Mark’s Basilica and the Doge’s Palace. Starting your day early will allow you to dodge the crowds.

Strolling from the San Marco Campanile to the Doge’s Palace leads you to the Riva degli Schiavoni, a scenic waterfront area that boasts stunning views of the canals, San Giorgio Maggiore, and the Bridge of Sighs.

As the crowds begin to swell, retreat to the more tranquil neighborhoods like Dorsoduro, Castello, and Cannaregio. While wandering through these areas, you might discover a hidden chapel or a dilapidated palazzo. Treat yourself to some Cicchetti in Dorsoduro to wrap up your day, complemented by a refreshing Bellini—after all, it was created right here.

Discover accommodations in Venice

Day Two

Florence

Florence is approximately a two-hour journey by high-speed train, so set off early to make the most of your day. Trains begin departing around 5:30 AM, running hourly from Venezia San Lucia to Florence Santa Maria Station.

Wander the charming cobbled streets to Piazza della Signoria, where you’ll find treasures like the Neptune fountain, crafted by Ammannati, and the Uffizi Gallery, which houses some of the most significant Renaissance artworks. Don’t forget to see Michelangelo’s David at the Galleria dell’Accademia.

If you’re up for a challenge, ascend the steps of the II Duomo to admire its stunning stained glass windows and artwork. Alternatively, cross the Ponte Vecchio—a picturesque covered bridge filled with shops—toward Piazzale Michelangelo for breathtaking views of Florence. On your return, sample fresh local produce at St. Lorenzo, the city’s oldest market.

Discover accommodations in Florence

Day Three

Rome

Just 90 minutes away by high-speed train, it might be tempting to linger in bed, but there’s so much to explore. Trains begin their journeys around 6:00 AM, leaving Santa Maria Novella for Rome Termini every 15 minutes.

With all its incredible sights, it’s impossible to see everything in Rome in a single day. However, a must-visit is the Colosseum, the largest amphitheater in the world. Be sure to toss a coin for good fortune at Neptune's feet at the Trevi Fountain before making your way to the Pantheon.

Vatican City

You can also venture beyond Rome to the Vatican, which is technically a separate country governed by the Pope. Here, you’ll discover Michelangelo’s renowned frescoes in the Sistine Chapel, while the Vatican Museums display invaluable paintings and artifacts.

If you’re visiting on a Wednesday, you might catch a glimpse of the Pope at St. Peter’s Square, where he addresses the public whenever he’s in Rome. Don’t miss Forno Campo de’Fiori in Centro Storico for their famous Roman pizza bianco.

Discover accommodations in Rome

Day Four

Naples

High-speed trains from Rome Termini to Naples Centrale begin their service around 7:00 AM, operating hourly at first and increasing frequency after 9:00 AM.

Make your way to the historic center of Naples, one of the oldest in the world. Stroll along Via San Gregorio Armeno, famously known as Christmas Alley, where artisan shops sell exquisite nativity figurines. Here, you’ll also find one of Naples’ most iconic churches.

Savor a seafood lunch paired with a glass of local Fiano di Avellino wine before heading to Pompeii for the afternoon. Take the Trenitalia train from Napoli Piazza Garibaldi to Pompeii; it’s a quick ride of about 40 minutes, bringing you to the city center near Piazza Anfiteatro, the less busy entrance to the amphitheater. Don’t miss Villa dei Misteri, home to some of Italy’s most stunning frescoes, or head directly to the ruins.

Amalfi

If Pompeii doesn’t pique your interest, no worries. Complete your exploration of the Centro Storico and catch a train from Napoli Piazza Garibaldi to Vietri Sul Mare Amalfi, which takes approximately 75 minutes. Trains run frequently, but be on the lookout for a direct service. You’ll have the entire afternoon to explore this charming town before the last train departs around 9:45 PM, getting you back just after 11 PM.

Wander through the narrow streets that showcase a blend of Mediterranean, Norman, and Saracen influences, reflected in the local architecture. Be sure to try the local pastries—Delizia al Limone is a beloved treat among both tourists and residents. The coastline is also famous for its exceptional restaurants that serve the freshest ingredients.

Discover accommodations in Naples

Day Five

Sicily

Board the InterCity train from Naples Centrale at 9:50 AM and travel south along the Calabrian coast to Sicily. Although it’s a long journey, you'll have the chance to recharge and experience one of the most unique train rides. The entire train boards a ferry to cross the Strait of Messina into Sicily—this experience alone makes the trip worthwhile!

Upon arriving in Sicily, you’ll need to make a decision as the train splits; you can travel south to Taormina, arriving around 4:40 PM, or Catania by approximately 5:25 PM. Alternatively, continue east to Palermo, the capital city of Sicily, reaching it at about 7:25 PM.

Day Six

Palermo

Take your time to savor the culinary delights of Palermo, which recently earned a spot among the world’s Top 20 Street Food Cities. Make your way to Piazza Vigliena, an iconic eight-sided intersection known across Europe.

The streets are dotted with inviting al fresco restaurants offering authentic local dishes. Treat yourself to a coffee and cannoli at Caffe Spinnato, a beloved spot since 1860. For street food, visit Mercato del Capo, particularly lively in the evenings. This is the local hotspot, and to mingle with residents, check out Ke Palle. If you prefer the beach, Mondello Beach is just a 15-minute drive away.

Discover accommodations in Palermo

Ticket Purchases

The most economical option for your journey is to purchase a pass that is valid for four days within a month. Be aware that an additional fee may apply when traveling on high-speed trains. You can book your tickets directly through Trenitalia or ItaliaRail.