25 Top Destinations to Explore in South America, from Brazil's Wetlands to Easter Island

Machu Picchu, Peru

Machu Picchu, one of the most renowned destinations globally, offers an experience like no other. This historical site, originally an Inca citadel built around the 1450s, is often referred to as 'The Lost City of the Incas.' Located approximately 50 miles from Cusco, visitors can reach it by train to Aguas Calientes, followed by a bus ride to the site. Tours are mandatory, so be sure to book your spots well in advance. According to Huarancca, 'Visiting Machu Picchu is possible year-round; various climatic conditions add to its enigmatic charm.' If you wish to dodge the rain, he suggests planning your trip from April to the end of October.

Jardín, Antioquia, Colombia

Jardín is a quaint town located a few hours south of Medellín, known for its colonial architecture, stunning landscapes, and numerous activities. During my visit, I stayed at Creo Ecolodge, where Castro shared plenty of great suggestions. Be sure to explore the Cueva del Esplendor, or "Cave of Splendor," featuring a breathtaking waterfall, or visit a local coffee farm to discover the process behind Colombian coffee production. My top pick is Cafe Historias, home to some of the finest coffee I’ve ever enjoyed. Castro recommends visiting in August and September, when the crowds are minimal. This period also coincides with the annual Jardín Film Festival, although the town becomes much busier from December to April.

Buenos Aires, Argentina

In Buenos Aires, one of my all-time favorite cities, you'll discover everything from lively tango performances and vibrant street art to the most delicious steak imaginable. Each neighborhood boasts its own unique charm. Visit La Boca to admire stunning murals lining the streets, then explore the iconic cemetery in Recoleta before unwinding at a speakeasy in Palermo. The city offers an abundance of amazing activities, making it an ideal base for exploring more of Argentina.

Valparaíso, Chile

Just under two hours from Santiago, this charming coastal city was the former home of renowned poet and diplomat Pablo Neruda. Valparaíso is known for its whimsical, colorful hillside homes, vintage funiculars, and breathtaking ocean vistas. It’s also close to Viña del Mar, where some of Chile's finest beaches await.

Galápagos Islands, Ecuador

The Galápagos Islands are a paradise for nature enthusiasts. Travelers can explore the archipelago's remarkable biodiversity, dive into the ocean's depths, relax on sandy shores, or join a multi-island cruise. You might even swim alongside playful sea lions or observe the majestic giant turtles up close.

Cocora Valley, Salento, Colombia

Located directly west of Bogotá, Cocora Valley is among Colombia's premier hiking spots. You can embark on a day trip from the nearby town of Salento or opt for a multi-day trek through the valley. Campsites are available if you wish to spend the night under the stars. This area is renowned for hosting the tallest palm trees globally, reaching heights of about 200 feet and living up to two centuries. The vibrant green hills are breathtaking. Castro strongly suggests visiting during "golden hour," either early morning or late afternoon, for the most spectacular views.

The Rock of Guatapé, Colombia

The town of Guatapé, located in northern Colombia just east of Medellín, is renowned for its iconic Rock, which can be climbed via over 700 steps. Once you reach the top, you're greeted with breathtaking views of the town and the islands dotting the expansive Peñol-Guatapé Reservoir. Accessible by bus and less than two hours from Medellín, it's an ideal destination for a weekend getaway. 'The locals here are exceptionally friendly and welcoming,' says Castro. 'As you stroll through the town, you'll encounter many smiling faces… it's a reflection of our culture.'

San Rafael, Antioquia, Colombia

San Rafael is perfect 'if you're seeking a profound connection with yourself and nature,' according to Castro. She suggests Vanadurga Ashram, a yoga retreat, for those wishing to deepen their practice while visiting. 'These places possess a certain magic, and you can learn to shift your perspective,' Castro adds.

Renowned for its stunning natural landscapes, San Rafael boasts mountains, waterfalls, and rivers. Here, you can engage in birdwatching, hiking, or simply immerse yourself in the great outdoors. 'People come here for an inner journey,' states Castro. 'If your aim is to discover something within, I’d highly recommend places like San Rafael.'

The Lost City, Magdalena, Colombia

The Lost City, known as Ciudad Perdida in Spanish, is situated near Santa Marta in northern Colombia. It is thought to have been established in the eighth or ninth century, making it several centuries older than Machu Picchu. This ancient site is believed to have housed around 2,000 inhabitants and featured approximately 170 terraces for living, working, and religious activities. Accessing it involves a trek lasting three to six days with a guided tour, where you’ll encounter unique native flora and fauna, adding to the adventure.

Cusco, Peru

For those captivated by Inca history, Cusco is an ideal destination. It serves as a fantastic launch point for trips to Machu Picchu, while also showcasing remnants of its Incan past alongside stunning colonial architecture. Many travelers spend several days here to explore and acclimatize to the high altitude of 11,150 feet—much higher than Denver’s elevation of 5,280 feet. The narrow streets, Baroque churches, and rich art and history museums will enchant you.

Rainbow Mountain, Vinicunca, Peru

Located near Cusco in the Andes, Vinicunca, or Rainbow Mountain, is famed for its stunning, multicolored stripes that can be seen all year round. These vibrant colors are the result of various mineral layers combined with melted ice, creating a spectacular display of reds, yellows, purples, and greens.

Amazon Rainforest, Peru

Spanning eight countries, the Amazon rainforest covers nearly 2.6 million square miles. You can explore the Peruvian Amazon from three main areas: Manú National Park, Tambopata Province, and the city of Iquitos. Each location offers a distinct experience for visitors. The best choice depends on your interests, available time, and budget. 'My only advice for international travelers is to book in advance and gather detailed information about your destinations,' advises Huarancca. 'It’s crucial to understand the local food, drinks, and traditions of the area.'

Huacachina, Peru

Huarancca suggests a visit to Huacachina, described as 'a small oasis in the heart of the desert.' Situated south of Lima and close to Ica, this desert village is surrounded by sweeping sand dunes. While swimming in Huacachina Lagoon isn't allowed, you can rent paddleboats to glide across its surface. It is the only natural oasis in South America, created by underground aquifers.

Colca Canyon, Peru

In Peru, Colca Canyon is a must-see destination that Huarancca highly recommends. It ranks among the deepest canyons in the world, measuring twice the depth of the Grand Canyon. You can opt for a day trip from Arequipa or embark on a multi-day trek for the most stunning views. Regardless of your choice, expect to encounter diverse native wildlife and breathtaking landscapes.

Lake Titicaca, Peru and Bolivia

Lake Titicaca spans two countries in South America, making it the continent's largest freshwater lake and the highest navigable lake in the world. Estimated to be around three million years old, it features human-made islands constructed from layers of totora reeds and roots. The number of islands fluctuates, typically ranging from 60 to over 100. This region holds significant cultural importance for the indigenous communities of Peru and Bolivia, offering some of the most spectacular views in the Andes.

Uyuni Salt Flat, Bolivia

Once a prehistoric lake that dried up, Bolivia's salt flats are the largest in the world. The Uyuni Salt Flat spans approximately 4,200 square miles, showcasing stunning white salt crusts and rock formations. If you visit between December and April during the rainy season, you might spot bright pink flamingos. Many travelers who experience the water-covered flats describe it as walking on a cloud, with the sky mirrored in the water. For a unique experience, book a stay at the Luna Salada Hotel, located nearby and constructed entirely of salt.

Pantanal Wetland, Brazil

Covering over 40 million acres, Brazil's Pantanal Wetland is the largest wetland on the planet. It is also one of the most biodiverse areas in the world, home to more than 4,700 species of plants and animals, including jaguars and crocodiles. Balardjischvili advises, 'Be sure to bring insect repellent, a lightweight raincoat, and a sweatshirt — and stay hydrated.'

Petrópolis, Brazil

Once a royal summer getaway in the 19th century, Petrópolis is a mountain resort city located just outside of Rio de Janeiro, renowned for its palaces, stunning architecture, and delicious cuisine. 'Take a guided tour of Petrópolis to appreciate its historical significance,' advises Balardjischvili. 'Always ensure your tour is booked with reputable companies that have positive reviews.'

Christ the Redeemer, Rio de Janeiro, Brazil

Christ the Redeemer is recognized as one of the New 7 Wonders of the World and is an essential stop for anyone visiting Brazil. This impressive statue of Jesus rises nearly 125 feet high, overlooking Rio de Janeiro. Expect breathtaking views of the city when you visit. Balardjischvili suggests purchasing a ticket in advance for the train ride to the statue.

Sugarloaf Mountain, Rio de Janeiro, Brazil

Sugarloaf Mountain is an iconic landmark in Brazil, famous for its sweeping views of the city from the summit. When the cable car system opened in 1912, it became the first of its kind in Brazil and the third globally. 'For Sugarloaf, it's best to visit in the morning when it's less crowded; while the sunset is stunning, it draws large crowds,' advises Balardjischvili. 'If you’re visiting during peak season, consider buying a skip-the-line ticket.' The peak rises nearly 1,300 feet, so you’ll appreciate not having to hike all the way up.

When discussing the ideal time to visit Rio de Janeiro, Balardjischvili recommends May or June, noting that during these months, "you’ll experience beautiful sunny days with no rain and temperatures around 77 degrees."

Iguazú Falls, Puerto Iguazú, Argentina

Straddling the border between Argentina and Brazil, Iguazú Falls consists of approximately 275 distinct waterfalls, making it one of the largest waterfall systems globally. While the majority of the waterfalls are located on the Argentine side, the tallest is found on the Brazilian side. It's a breathtaking sight and a must-visit for anyone exploring South America.

Patagonia, Argentina

Spanning more land than many countries, Patagonia is divided between Argentina and Chile, with each city offering its own distinct character. Notable cities in Argentine Patagonia include El Calafate, Ushuaia, and El Chaltén. Whether you're sampling craft brews at Patagonia Brewery in San Carlos de Bariloche or exploring one of the region's 300 glaciers, you're guaranteed an unforgettable adventure.

Zuccardi Winery, Uco Valley, Argentina

Wine lovers should definitely indulge in some tastings before leaving Argentina. Zuccardi Valle de Uco, an acclaimed winery, offers exceptional wines alongside breathtaking views of the Andes, enhancing the beauty of its sprawling vineyards. You can easily book tastings and tours online.

Punta del Este Beaches, Uruguay

Uruguay remains somewhat underrated, yet it offers a wonderful experience for international visitors. A short ferry ride of just a few hours will take you from Buenos Aires, Argentina, to Montevideo, the capital of Uruguay. From Montevideo, it's a two-hour drive to Punta del Este, known for its stunning beaches, upscale shopping, and fantastic steakhouses.

Easter Island, Chile

Easter Island is a territory of Chile located in the South Pacific Ocean, approximately a 5.5-hour flight from Santiago. This secluded destination is home to nearly 1,000 stone statues of human figures known as moai, believed to have been crafted between the 10th and 16th centuries.